Filter and export

Publications

What is a Publication?
16 Publications visible to you, out of a total of 16
Determinants of Influenza A infection rate in post-COVID-19 era.

Abstract

Not specified

Authors: I. Wagenhauser, J. Mees, J. Reusch, T. T. Lam, A. Schubert-Unkmeir, L. B. Krone, A. Frey, O. Kurzai, S. Frantz, L. Dolken, J. Liese, A. Gabel, N. Petri, M. Krone

Date Published: 11th Sep 2023

Publication Type: Journal

Inability to work following COVID-19 vaccination-a relevant aspect for future booster vaccinations.

Abstract (Expand)

OBJECTIVES: COVID-19 vaccination is a key prevention strategy to reduce the spread and severity of SARS-CoV-2 infections. However, vaccine-related inability to work among healthcare workers (HCWs) could … overstrain healthcare systems. STUDY DESIGN: The study presented was conducted as part of the prospective CoVacSer cohort study. METHODS: This study examined sick leave and intake of pro re nata medication after the first, second, and third COVID-19 vaccination in HCWs. Data were collected by using an electronic questionnaire. RESULTS: Among 1704 HCWs enrolled, 595 (34.9%) HCWs were on sick leave following at least one COVID-19 vaccination, leading to a total number of 1550 sick days. Both the absolute sick days and the rate of HCWs on sick leave significantly increased with each subsequent vaccination. Comparing BNT162b2mRNA and mRNA-1273, the difference in sick leave was not significant after the second dose, but mRNA-1273 induced a significantly longer and more frequent sick leave after the third. CONCLUSION: In the light of further COVID-19 infection waves and booster vaccinations, there is a risk of additional staff shortages due to postvaccination inability to work, which could negatively impact the already strained healthcare system and jeopardise patient care. These findings will aid further vaccination campaigns to minimise the impact of staff absences on the healthcare system.

Authors: J. Reusch, I. Wagenhauser, A. Gabel, A. Hohn, T. T. Lam, L. B. Krone, A. Frey, A. Schubert-Unkmeir, L. Dolken, S. Frantz, O. Kurzai, U. Vogel, M. Krone, N. Petri

Date Published: 25th Aug 2023

Publication Type: Journal

Bivalent BNT162b2 mRNA original/omicron BA.4-5 booster vaccination: adverse reactions and inability to work compared with the monovalent COVID-19 booster.

Abstract

Not specified

Authors: I. Wagenhauser, J. Reusch, A. Gabel, L. B. Krone, O. Kurzai, N. Petri, M. Krone

Date Published: 4th Apr 2023

Publication Type: Journal

Clinical accuracy of SARS-CoV-2 rapid antigen testing in screening children and adolescents.

Abstract

Not specified

Authors: M. Krone, I. Wagenhauser, K. Knies, D. Hofmann, G. Engels, R. Taurines, M. McDonogh, S. Flemming, T. Meyer, H. Bohm, A. Scherzad, M. Eisenmann, V. Rauschenberger, A. Gabel, N. Petri, J. Reusch, J. Forster, B. Weissbrich, L. Dolken, O. Kurzai, U. Vogel, C. Hartel, J. Liese, O. Andres

Date Published: 25th Dec 2022

Publication Type: Journal

Immunogenicity and safety of coadministration of COVID-19 and influenza vaccination.

Abstract (Expand)

Coadministration of seasonal quadrivalent influenza and COVID-19 booster vaccination is safe and does not increase vaccine-related side-effects, but may limit anti-SARS-CoV-2 antibody formation … https://bit.ly/3uKFUie

Authors: I. Wagenhauser, J. Reusch, A. Gabel, A. Hohn, T. T. Lam, G. Almanzar, M. Prelog, L. B. Krone, A. Frey, A. Schubert-Unkmeir, L. Dolken, S. Frantz, O. Kurzai, U. Vogel, N. Petri, M. Krone

Date Published: 23rd Dec 2022

Publication Type: Journal

Influencing factors of anti-SARS-CoV-2-spike-IgG antibody titers in healthcare workers: A cross-section study.

Abstract (Expand)

Against the background of the current COVID-19 infection dynamics with its rapid spread of SARS-CoV-2 variants of concern (VOC), the immunity and the vaccine prevention of healthcare workers (HCWs) … against SARS-CoV-2 continues to be of high importance. This observational cross-section study assesses factors influencing the level of anti-SARS-CoV-2-spike IgG after SARS-CoV-2 infection or vaccination. One thousand seven hundred and fifty HCWs were recruited meeting the following inclusion criteria: age >/=18 years, PCR-confirmed SARS-CoV-2 infection convalescence and/or at least one dose of COVID-19 vaccination. anti-SARS-CoV-2-spike IgG titers were determined by SERION ELISA agile SARS-CoV-2 IgG. Mean anti-SARS-CoV-2-spike IgG levels increased significantly by number of COVID-19 vaccinations (92.2 BAU/ml for single, 140.9 BAU/ml for twice and 1144.3 BAU/ml for threefold vaccination). Hybrid COVID-19 immunized respondents (after infection and vaccination) had significantly higher antibody titers compared with convalescent only HCWs. Anti-SARS-CoV-2-spike IgG titers declined significantly with time after the second vaccination. Smoking and high age were associated with lower titers. Both recovered and vaccinated HCWs presented a predominantly good humoral immune response. Smoking and higher age limited the humoral SARS-CoV-2 immunity, adding to the risk of severe infections within this already health impaired collective.

Authors: J. Reusch, I. Wagenhauser, A. Gabel, A. Eggestein, A. Hohn, T. T. Lam, A. Frey, A. Schubert-Unkmeir, L. Dolken, S. Frantz, O. Kurzai, U. Vogel, M. Krone, N. Petri

Date Published: 13th Nov 2022

Publication Type: Journal

Virus variant-specific clinical performance of SARS coronavirus two rapid antigen tests in point-of-care use, from November 2020 to January 2022.

Abstract (Expand)

OBJECTIVES: Antigen rapid diagnostic tests (RDTs) for SARS coronavirus 2 (SARS-CoV-2) are quick, widely available, and inexpensive. Consequently, RDTs have been established as an alternative and … additional diagnostic strategy to quantitative reverse transcription polymerase chain reaction (RT-qPCR). However, reliable clinical and large-scale performance data specific to a SARS-CoV-2 virus variant of concern (VOC) are limited, especially for the Omicron VOC. The aim of this study was to compare RDT performance among different VOCs. METHODS: This single-centre prospective performance assessment compared RDTs from three manufacturers (NADAL, Panbio, MEDsan) with RT-qPCR including deduced standardized viral load from oropharyngeal swabs for detection of SARS-CoV-2 in a clinical point-of-care setting from November 2020 to January 2022. RESULTS: Among 35 479 RDT/RT-qPCR tandems taken from 26 940 individuals, 164 of the 426 SARS-CoV-2 positive samples tested true positive with an RDT corresponding to an RDT sensitivity of 38.50% (95% CI, 34.00-43.20%), with an overall specificity of 99.67% (95% CI, 99.60-99.72%). RDT sensitivity depended on viral load, with decreasing sensitivity accompanied by descending viral load. VOC-dependent sensitivity assessment showed a sensitivity of 42.86% (95% CI, 32.82-53.52%) for the wild-type SARS-CoV-2, 43.42% (95% CI, 32.86-54.61%) for the Alpha VOC, 37.67% (95% CI, 30.22-45.75%) for the Delta VOC, and 33.67% (95% CI, 25.09-43.49%) for the Omicron VOC. Sensitivity in samples with high viral loads of >/=10(6) SARS-CoV-2 RNA copies per mL was significantly lower in the Omicron VOC (50.00%; 95% CI, 36.12-63.88%) than in the wild-type SARS-CoV-2 (79.31%; 95% CI, 61.61-90.15%; p 0.015). DISCUSSION: RDT sensitivity for detection of the Omicron VOC is reduced in individuals infected with a high viral load, which curtails the effectiveness of RDTs. This aspect furthert: limits the use of RDTs, although RDTs are still an irreplaceable diagnostic tool for rapid, economic point-of-care and extensive SARS-CoV-2 screening.

Authors: I. Wagenhauser, K. Knies, D. Hofmann, V. Rauschenberger, M. Eisenmann, J. Reusch, A. Gabel, S. Flemming, O. Andres, N. Petri, M. S. Topp, M. Papsdorf, M. McDonogh, R. Verma-Fuhring, A. Scherzad, D. Zeller, H. Bohm, A. Gesierich, A. K. Seitz, M. Kiderlen, M. Gawlik, R. Taurines, T. Wurmb, R. I. Ernestus, J. Forster, D. Weismann, B. Weissbrich, L. Dolken, J. Liese, L. Kaderali, O. Kurzai, U. Vogel, M. Krone

Date Published: 27th Aug 2022

Publication Type: Journal

Powered by
 (v.1.16.1)
About NFDI4Health | About Local Data Hub Universitätsklinikum Würzburg | Partners and Funding | Credits
Copyright © 2008 - 2023 The University of Manchester and HITS gGmbH