ARIPro

Overview

Overview
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Sponsor: University Hospital Würzburg

SEEK ID: https://ldh.uk-wuerzburg.imise.uni-leipzig.de/projects/8

Public web page: https://redcap.ukw.de/surveys/?s=3THTNNER79XT8JKF

NFDI4Health PIs: No PIs for this Trial Project

Trial Project start date: 1st Apr 2024

Trial Project end date: 31st Dec 2027

Extended Metadata (Nfdi4Health MDS 3.3)

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Id of the project(*) : 29408

Resource classification(*)

Type of the resource(*) : Study

Title(s)/name(s) of the Project

Title/name(*) : ARIPro – Untersuchung der Inzidenz, Risikofaktoren und Impfpräventabilität von akuten respiratorischen Infektionen und deren Auswirkungen auf Lebensqualität, Arbeitsfähigkeit und Arbeitsausfall
Language of the title/name(*) : German

Title/name(*) : ARIPro - Investigation of the Incidence, Risk Factors, and Vaccine Preventability of Acute Respiratory Infections and Their Impact on Quality of Life, Work Ability, and Absence from Work
Language of the title/name(*) : English

Acronym(s) of the Project

Acronym(*) : ARIPro
Language of the acronym(*) : German

Acronym(*) : ARIPro
Language of the acronym(*) : English

Description(s) of the Project

Description(*) : Die ARIPro-Studie ist eine prospektive Kohortenstudie, die die jährliche Seroinzidenz akuter respiratorischer Infektionen (ARI) bei Beschäftigten im Gesundheitswesen (healthcare workers, HCWs) untersucht. Daneben werden Faktoren, die diese beeinflussen, die Auswirkungen von ARI auf Lebensqualität, Arbeitsfähigkeit sowie Arbeitsausfall, die Effekte verschiedener Impfschemata auf diese sowie Faktoren, die Impfpräferenzen bei HCWs beeinflussen, untersucht. HCWs sind einer erhöhten ARI-Exposition ausgesetzt. Dies stellt wiederum für vulnerable Patienten durch nosokomiale Infektionen ein Risiko dar. ARI-bedingte Krankheitsausfälle beeinträchtigen allwinterlich die Leistungsfähigkeit des Gesundheitssystems und gefährden damit unmittelbar die Patientenversorgung. In verschiedenen Ländern gibt es unterschiedliche Empfehlungen zur jährlichen COVID-19- und Influenza-Impfung als Präventionsstrategie auf schwacher Datenbasis. Daten werden zweimal im Jahr, vor und nach der winterlichen ARI-Saison erhoben: Ein Fragebogen erfasst Informationen zu demografischen Daten, Impfgeschichte und Gesundheitszustand inklusive der strukturierten Abfrage der Lebens- und Arbeitsqualität. Eine Blutprobe wird sowohl auf impfinduzierte als auch auf ausschließlich infektionsinduzierte Antikörper gegen SARS-CoV-2, Influenza und RSV analysiert. Es wird erwartet, dass die ARIPro-Studie wichtige Erkenntnisse über die Dynamik und Prävention von ARI bei HCWs liefert. Die Ergebnisse der Studie können verwendet werden, um Impfempfehlungen und -strategien für HCWs und weitere ähnliche Zielgruppen zu verbessern.
Language of the description(*) : German

Description(*) : The ARIPro study is a prospective cohort study investigating the annual seroincidence of acute respiratory infections (ARI) among healthcare workers (HCWs). Additionally, it examines factors influencing these infections, the impact of ARI on quality of life, work ability, and absenteeism, the effects of various vaccination schedules on these outcomes, and factors influencing vaccination preferences among HCWs. HCWs face increased exposure to ARI, posing a risk to vulnerable patients through nosocomial infections. ARI-related absenteeism annually affects healthcare system performance, directly jeopardizing patient care. Different countries have varying recommendations regarding annual COVID-19 and influenza vaccination as a preventive strategy, often based on limited data. Data is collected twice a year, before and after the winter ARI season. A questionnaire gathers demographic information, vaccination history, and health status, including structured inquiries into quality of life and work. Blood samples are analyzed for both vaccine-induced and infection-induced antibodies against SARS-CoV-2, Influenza, and RSV. The ARIPro study is expected to yield valuable insights into the dynamics and prevention of ARI among HCWs. Its results can inform improved vaccination recommendations and strategies for HCWs and similar target groups.
Language of the description(*) : English

Keyword(s) describing the Project

Keyword(*) : Acute respiratory infection

Keyword(*) : Vaccination

Language(s) of the project : English, German

Contributor(s) of the Project

Is it a personal or organisational contribution?(*) : Organisational
Details about the contributing organisation(s)/institution(s)/group(s)
Contributor type(*) : Sponsor (primary)
Funding identifier(s) : Not specified
Name of the organisation/institution/group(*) : Universitätsklinikum Würzburg
Details about the contributing person(s)
Contributor type(*) : Not specified
Given name(*) : Not specified
Family name(s)(*) : Not specified
Digital identifier(s)
Identifier(*) : Not specified
Scheme(*) : Not specified
Email address : Not specified
Phone number : Not specified
Organisation(s) associated with the contributor
Name(*) : Not specified
Address : Not specified
Web page : Not specified
Digital identifier(s)
Identifier(*) : Not specified
Scheme(*) : Not specified

Is it a personal or organisational contribution?(*) : Personal
Details about the contributing organisation(s)/institution(s)/group(s)
Contributor type(*) : Not specified
Funding identifier(s) : Not specified
Name of the organisation/institution/group(*) : Not specified
Details about the contributing person(s)
Contributor type(*) : Principal investigator
Given name(*) : Manuel
Family name(s)(*) : Krone
Digital identifier(s)
Identifier(*) : Not specified
Scheme(*) : Not specified
Email address : krone_m@ukw.de
Phone number : Not specified
Organisation(s) associated with the contributor
Name(*) : Not specified
Address : Not specified
Web page : Not specified
Digital identifier(s)
Identifier(*) : Not specified
Scheme(*) : Not specified
Identifier(*) : Not specified
Scheme(*) : Not specified
Name(*) : Not specified
Address : Not specified
Web page : Not specified
Digital identifier(s)
Identifier(*) : Not specified
Scheme(*) : Not specified
Identifier(*) : Not specified
Scheme(*) : Not specified

Alternative identifiers

Type of the registry(*) : Not specified
Identifier(*) : Not specified

Characteristics of the Project

Is it an interventional or non-interventional Project? : Non-interventional
Specification of the type of the Project
Interventional Project type : []
Non-interventional Project type : Cohort
Primary health condition(s) or disease(s) considered in the Project
Primary health condition or disease name(*) : Acute respiratory infections
Terminology/classification(*) : SNOMED CT
Code of the health condition or disease : 195647007
Groups of diseases or conditions(*)
Which groups of diseases or conditions were the data collected on? : Certain infectious or parasitic diseases (I)
On which diseases or conditions were the data collected? : []
Collects mortality data? : Not specified
Administrative information about the Project
Status of the ethics committee approval : Request for approval submitted, approval granted
Overall Project status : Ongoing (III): Recruitment completed, but data collection ongoing
Participants enrolled by invitation? : Not specified
Start date : 1 April 2024
End date : 30 April 2027
Mono- or multicentric? : Not specified
Number of centers : Not specified
One or more data providers? : Not specified
Number of data providers : Not specified
Primary subject(*) : Person
Eligibility criteria for Project participants
Eligibility criteria: Minimum age
Minimum eligible age(*) : 18
Unit of age(*) : Years
Eligibility criteria: Maximum age
Maximum eligible age(*) : 99
Unit of age(*) : Years
Eligible gender : []
Inclusion criteria : Not specified
Exclusion criteria : Not specified
Population of the Project(*)
Coverage : Regional
Country(ies) : Germany
Region(s) and/or city(ies) : Not specified
Interventions of the Project
Name of the intervention(*) : Not specified
Type of the intervention : Not specified
Additional information about the intervention : Not specified
Name(s) of the arm(s) associated with the given intervention : Not specified
Exposures of the Project
Name of the exposure : Not specified
Type of the exposure : Not specified
Additional information about the exposure : Not specified
Name(s) of the group(s) associated with the given exposure : Not specified
Outcome measures in the Project
Name of the outcome measure(*) : Not specified
Description of the outcome measure : Not specified
Type of the outcome measure : Not specified
Time point(s) of assessment : Not specified
Additional information about the Project : Not specified
Additional assessments/measurements in the Project : []
Data sharing strategy of the Project(*)
Is it planned to share the data?(*) : Yes, there is a plan to make data available
Supporting documents available in addition to the data : []
When and for how long will the data be available? : Not specified
Criteria for data access : Not specified
Additional information about data sharing : Not specified
DataSHIELD/Opal infrastructure available? : Not specified
Link to data request application : Not specified
Web page with additional information about data sharing : Not specified
Record linkage possible? : false
Non-interventional aspects of the Project
Temporal design : []
Target follow-up duration of the Project
Target follow-up duration(*) : Not specified
Unit of time(*) : Not specified
Number of follow-ups conducted : Not specified
Biosamples retained in a biorepository : []
Specific types of retained biosamples : Not specified
Interventional aspects of the Project
Numerical phase : Not specified
Masking of intervention(s) assignment
Masking implemented? : Not specified
Who is masked? : []
Additional information about masking : Not specified
Type of allocation of participants to an arm : Not specified
Off-label use of a drug product : Not specified

ARIPro

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